In the body, nicotine interacts with central nervous system receptors consisting of various combinations of alpha and beta proteins. This facilitates the release of neurotransmitters such as dopamine, norepinephrine, acetylcholine, glutamate, and serotonin. The dependence produced is similar to that of opiates and cocaine (Johnson, Rose & Westman, 1999). Pharmacologically, the nicotine produces feelings of pleasure, arousal, and relaxation, amd may improve attention and reaction time in addicted individuals. Also, the use of nicotine reduces anxiety and stress, relieves hunger, and prevents weight gain (Hunter et al., 1994). The negative effects of the drug include increased blood pressure, heart rate, coronary vasoconstriction, and the production of carboxyhemoglobin, which reduces the delivery of oxygen in the body (Ferry, Joseph, Norman, & Prochazka, 1996). Not only does nicotine effect the body biologically, but it has serious psychoactive effects as well. These psychoactive effects cause the smoker’s behavior to be reinforced, both positively and negatively. The positive reinforcement (which causes the smoker to want to smoke) involves the stimulation of the nicotine receptors, which promotes higher rates of self-administration of the drug. The negative reinforcement (which causes the smoker to not want to not smoke) is in the form of withdrawal symptoms produced by chronic use. Smokers also associate the pleasurable effects of smoking mentioned previously with the taste, smell, and feel of the smoke in their throat, as well as the manipulation of the smoking materials. This is called conditioning, which is the major cause of relapse once smoking cessation has occurred (Hunter et al.). In order for an individual to quit smoking, the psychological, behavioral, and physical components of addiction must be considered so that an effective treatment plan can be developed. The most successful approaches involve a combination of behavior modification programs along with effective pharmacological agents. One of the best pharmacological approaches is nicotine replacement therapy, which reduces the craving and minimizes the physical withdrawal symptoms of nicotine (Hunter et al.). Three of the most widely used tools for nicotine replacement therapy are nicotine polacrilex (nicotine gum), the transdermal nicotine patch, and the nicotine nasal spray. However, each method is unique and the positive and negative aspects need to be considered by the individual when a therapy is being se