"Cold turkey" defines the actions of an individual who brusquely gives up an addiction or habit instead of slowly simplifying the practice through slow reduction or by using replacement medicine. By not aggressively utilizing methods of supplement, the supposed benefit is that the addict evades thinking about the addiction, along with its temptation, and evades additional feeding of the habit. Associated with the abuse of drugs, for example, benzodiazepines and alcohol, the supposed drawbacks are intolerable withdrawal signs from the total abstinence, which may become the reason of terrific stress on the blood vessels and heart. A number of these similar symptoms are shared by heroin withdrawal, though deaths only take place in treatments of "rapid-detox" together with other administered medicines, for example Naloxone or Naltrexone. This paper is aimed at the cause and effect of Coke withdrawal with the Cold Turkey Challenge. As a drug, when cocaine is consumed it is related to the discharge of dopamine and additional “feel good neurotransmitters” in the brain. By averting the reuptake of dopamine, norepinephrine, and serotonin simultaneously, it acts as a triple reuptake inhibitor (TRI). This leads an individual to get a stimulating effect, decreased appetite, and feeling euphoric. Because of the fact that it encourages the mesolimbic reward way in the process, it is well-thought of as very addictive. “While the Coca-Cola Company officially denies the presence of cocaine in any of its products - past or present - historical evidence suggests that the original Coca-Cola did, in fact, contain cocaine” (Elizabeth Palermo, 2013). It is thought of as an unsafe drug because of the fact of high doses, which block channels of sodium, which can lead to cardiac death. It is generally considered, for this reason, as being more unsafe than other drugs – comprising amphetamines. It crosses the barrier of blood-brain quicker than most