Till the end of the 19th century, in some countries nearly till the middle of 20th century, a woman was required to stay at home and to be busy only with house works and to care with family members, while a man's role was at work. Men had power and authority, and women, contradictory to men, were expected to be humble, subservient and conformist. In "One Flew Over the Cuckoo's Nest", Ken Kesey reverses the stereotypical gender roles. Contrary to the general idea, the novel has powerful, disobedient and dangerous female characters such as Nurse Ratched, Mrs. Bibbit, and Vera Harding. It seems that men are how innocent, how they are cotrolled by women and also heroic and good with the characters of the novel such as Mr. McMurphy, Billy Bibbit and Mr. Harding. The aim of this article is focusing on these characters and analyzing them in terms of gender roles, feminism and anti-feminism and sexism. In "One Flew Over the Cuckoo's Nest" almost all the female characters who have power to control are demonized and represent evil beings because they are emasculating the men. The supervisor Nurse Ratched is the head of this "emasculating progress" and the main enemy. Her behaviours toward patients depend on humiliating, minimizing them and sarcasm with them. Her way of controlling described by the patient Mr. McMurphy as "... is to weaken you by gettin’ you where it hurts the worse" (Kesey 54) because she chooses the sensitive subjects, which are actually available to talk in a personal therapy, to talk in a group therapy. For example, Mrs. Retched makes Mr. Harding to talk about his wife's use of her attractiveness to take other men's attention. Considering adultery is an embarrassing issue for both genders, Mrs. Retched's aim is very obvious. Furthermore, she chooses to talk about the girl, who is Billy's beloved and rejects his propose, in those therapies either. It is inferred from both novel and the movie that Mrs. Retched weakens her pa